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Instant SIM is a technique pioneered by York et al and developed commercially by Visitech International Ltd. The concept uses the Image Scanning Microscopy (ISM) approach described mathematically by Colin Sheppard in 1988. The technology creates a super-resolution image in analogue form using optics alone so that the image produced by the camera requires no reconstruction, although deconvolution improves the resolution further.

For iSIM at the LMCB, use GFP4.

Airyscan

Airyscan is another ISM technique developed by Carl Zeiss and implemented on the company's LSM confocal microscopes.

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